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Pikapolonica

http://jcem.endojournals.org/cgi/content/abstract/92/5/1715

Journal of Clinical Endocrinology & Metabolism, doi:10.1210/jc.2006-1869

Departments of Endocrinology (S.R., L.I., J.U.W.) and Biochemistry (G.K.), Queen Elizabeth Hospital, Gateshead NE9 6SX, United Kingdom; Department of Regional Medical Physics (C.O.), Newcastle General Hospital, Newcastle upon Tyne NE4 6BE, United Kingdom; Department of Psychology (C.M.), Health Psychology Research, Royal Holloway, University of London, Egham TW20 0EX, United Kingdom; and Department of Diabetes and Endocrinology (S.R., J.U.W.), School of Clinical Medical Sciences, University of Newcastle, Newcastle upon Tyne NE2 4HH, United Kingdom

Address all correspondence and requests for reprints to: Dr. J. U. Weaver, Ph.D., F.R.C.P., School of Clinical Medical Sciences, Department of Diabetes and Endocrinology, University of Newcastle, Framlington Place, Newcastle upon Tyne NE2 4HH, United Kingdom. E-mail: j.u.weaver@ncl.ac.uk.

Context: Subclinical hypothyroidism (SCH) is defined as raised serum TSH levels with circulating thyroid hormones within the reference range. It is uncertain whether treatment of SCH with L-thyroxine improves cardiovascular (CV) risk factors and quality of life.

Objective: The objective of the study was to assess CV risk factors and patient-reported outcomes after treatment.

Design: This was a randomized, double-blind, crossover study of L-thyroxine and placebo.

Setting: The study was conducted with community-dwelling patients.

Patients: One hundred patients [mean age (SD) 53.8 (12) yr, 81 females] with SCH [mean TSH 6.6 (1.3) mIU/liter] without previously treated thyroid or vascular disease.

Intervention: Intervention consisted of 100 µg L-thyroxine or placebo daily for 12 wk each.

Measurements: Primary parameters were total cholesterol (TC) and endothelial function [brachial artery flow-mediated dilatation (FMD)], an early marker of atherosclerosis. Patient-reported outcomes were also assessed.

Results: L-thyroxine treatment reduced TC (vs. placebo) from 231.6 to 220 mg/dl, P < 0.001; low-density lipoprotein cholesterol from 142.9 to 131.3 mg/dl, P < 0.05; waist to hip ratio from 0.83 to 0.81, P < 0.006; and improved FMD from 4.2 to 5.9%, P < 0.001. Multivariate analysis showed that increased serum free T4 level was the most significant variable predicting reduction in TC or improvement in FMD. Furthermore, the symptom of tiredness improved on L-thyroxine therapy, but other patient-reported outcomes were not significantly different after correction for multiple comparisons.

Conclusion: SCH treated by L-thyroxine leads to a significant improvement in CV risk factors and symptoms of tiredness. The CV risk factor reduction is related to the increased level of achieved free T4 concentration.

lara-ula · Pridružen/-a: 06.05. 2007, 15:11 Prispevkov: 50

Ojla, Pikapolonica,

ko berem te številke, se mi sicer nekaj šajna. Poslušaj, kaj ko bi imela ti za nas (za tiste, ki bi si to želele) ob naših srečanjih tudi hitre tečaje angleščine, ti teksti pa bi bili učno gradivo? Wink

:P

To bi bila zame za učenje angleškega jezika boljša motivacija, kot tečaji tujih jezikov po ne vem kakšni sodobni andragoški metodi s sprostitvenimi vajami vred. :P :P :P

LP

Pikapolonica · Objavljeno: 02 Jun 2007 08:25 Naslov sporočila:

Povzetek zgornje raziskave bi bil, da so Angleži proučevali smiselnost zdravljenja subklinične hipotiroze (ko sta ft4 in ft3 se v normalnem območju, tsh pa malce ven ali na meji).
Rezultati so pokazali, da se z zgodnjim jemalnjem scitnicnega hormona oz vzdrzevanjem dovolj viskoke ravni hormona ft4 v krvi zmanjsa verjetnost za nastanek kardiovaskularnih bolezni (vrednost ft4 mocno vpliva na novo holesterola v krvi), zmanjsajo pa se tudi simptomi utrujenosti.
lp Pika

PS: Za tiste, ki jim ni čisto jasno kaj so tsh, ft4, ft3, naj si preberejo osnove v uvodu na to spletno stran oz v starih sporocilih, kjer so razlozene osnove delovanja scitnice.
Enostavneje receno, priporoča se zgodnje jemanje scitnicnih hormonov in vzdrzevanje dovolj visokih vrednosti prostega tiroksina, kar bi pomenilo, ce vam zdravnik rece, da je vse ok, ker ste znotraj normalnega obmocja, vi pa cutite, da niste ok, je potrebno preveriti, ali je vasa vrednost ft4 dovolj visoka in kaksnen je nivo holesterola (ob ustrezni prehrani in gibanju seveda). To bi bila kratka laicna razlaga.

lara-ula · Pridružen/-a: 06.05. 2007, 15:11 Prispevkov: 50

Pozdravljena,

hvala za prevod. Poslala sem ti zs. :D :D :D

Pikapolonica · Objavljeno: 02 Jun 2007 20:34 Naslov sporočila:

Hm cudno, nisem dobila zs?! No, enega vceraj zvecer od ule, ampak na tistega sem ze odgovorila.
Lp Pika

lara-ula · Pridružen/-a: 06.05. 2007, 15:11 Prispevkov: 50

Pozdravljena Pika,

očitno je z zs nekaj narobe. Ne bom več pošiljala zs. Tudi Lenchi sem poslala dve, pa nobenega ni dobila. In še pred dnevi GozdniVili, pa imam ravno tako občutek, da ni dobila. Sad

No ja, bomo pa v živo kakšno rekli, če se kdaj vidiva.
LP

GozdnaVila · Objavljeno: 03 Jun 2007 11:21 Naslov sporočila:

Ja res je Lara Ula nisem ga dobila. Lahko mi pises kar na mail: gozdnavila@hotmail.com

lp, Karmen

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