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The Link Between Subclinical Hypothyroidism and Metabolic Syndrome
From Mary Shomon,
Your Guide to Thyroid Disease.
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According to the National Heart Lung and Blood Institute, about 47 million adults in the United States (almost 25 percent of the population) have metabolic syndrome, a combination of risk conditions that increase the risk of heart disease, diabetes, and stroke. The number of people suffering from metabolic syndrome also is on the rise.
Now, researchers have discovered that low-normal thyroid function - a condition known as subclinical hypothyroidism - is a risk factor for metabolic syndrome.

What is Metabolic Syndrome?
Metabolic syndrome is the name given to a syndrome that is seen more often in people who are overweight or obese, and who have specific conditions that increase the risk of heart disease, diabetes, stroke, and other health problems. Metabolic syndrome is diagnosed when three out of the following five risk factors are evident:
A Large Waistline

This may be referred to as abdominal obesity, or being "apple-shaped" or having a "Buddha belly." But according to the National Cholesterol Education Program (NCEP) and the American Heart Association, the criteria for "large waistline" is measuring over 35 inches for women and over 40 inches for men.

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For people who are genetically predisposed to diabetes, the limits are even lower, at 31 to 35 inches for women and 37 to 39 inches for men.
Elevated Triglycerides / Being on Treatment for High Triglycerides

Triglycerides are a type of fat that circulates in the bloodstream and increases the risk of heart disease. An elevated level is considered to be 150 milligrams per deciliter (mg/dL) or higher.

Low HDL / Being on Treatment for Low HDL

High-density lipoprotein (HDL) is a type of cholesterol often referred to as the "good" cholesterol, because it helps lower your risk of heart disease. A level of less than 40 mg/dL in men or less than 50 mg/dL in women is considered low.

Elevated Blood Pressure/ Treatment for High Blood Pressure

Blood pressure is recorded as two numbers, written one on top of or before the other, such as 120/80, or referred to as "120 over 80." The top number is the systolic blood pressure, and it's considered elevated if it goes above 130 and the bottom number - the diastolic - is considered elevated if it is above 85.

Elevated Fasting Blood Sugar / Treatment for Elevated Blood Sugar

Fasting blood sugar, also known as fasting glucose, can start to elevate as a warning sign of diabetes. A level of 100 mg/dL or higher is considered elevated.

As noted, at least three of the risk factors above qualify a person for a diagnosis of metabolic syndrome. But the more risk factors a person has, the greater the risk of heart disease, diabetes, or stroke. According to the NCEP, a person with metabolic syndrome is twice as likely to develop heart disease and five times as likely to develop diabetes as someone without metabolic syndrome.

Metabolic syndrome typically develops in people who are overweight or obese, who don't engage in physical activity, or who have a diet that promotes insulin resistance. Family history and age are also underlying causes.

The Thyroid Connection
Researchers have now found that even subtle changes in thyroid function increase the risk for metabolic syndrome.
The link between overt hypothyroidism and an increased risk of heart disease has already been established. But research published in the February 2007 issue of the Journal of Clinical Endocrinology and Metabolism found a connection between thyroid function and metabolic syndrome in people who have normal thyroid stimulating hormone (TSH) levels.

What the researchers found was that in those with normal TSH levels, the thyroid hormone level known as free T4 was important. Free T4 levels that were slightly low, but still within the normal range, significantly increased the risk of many risk factors for metabolic syndrome.

Lower levels of another thyroid hormone, free T3, were linked to risk factors including higher total cholesterol, LDL cholesterol, and triglycerides.

The researchers concluded that for people who have normal TSH levels, even slight changes in free T4 and free T3 levels can have an effect on the risk of metabolic syndrome and heart disease.

The researchers recommend that a study be done to determine whether early treatment of thyroid dysfunction might reduce the risk.

What This Means for You?
If future research does find that early treatment helps, free T4 and free T3, and not just TSH, will become key measurements in thyroid diagnosis and treatment decisions.
This research also suggests that if you are being treated for hypothyroidism, you should be monitored for signs of metabolic syndrome. If you are hypothyroid, you'll want to make every effort to reduce your metabolic syndrome risk factors.

Addressing the risk factors can be complex, but generally, involves a combination of any or all of the following approaches:

Overall efforts to lose weight, including diet and exercise
Specialized dietary changes to combat insulin resistance and improve cholesterol levels
Exercise
Medications to lower triglycerides, raise HDL, lower blood pressure, lower/manage blood sugar

Pikapolonica

Kratek poveztek je, da se scitnicarjem, ki imajo ths v normalnem obmocju in nekoliko nizke vrednosti ft4 in ft3, pogosto pojavi tako imenovani
metabolni sindrom:
- intoleranca na glukozo,
- visoki trigliceridi
- nizek HDL
- visok LDL
vrednost glukoze nad 100 mg/dl
trigliceridov: nad 150 mg/dl
HDL pod 50 mg/dl

Zato se za 50% poveca moznost srcnih obolenj in diabetesa.
Znacilno je tudi "Buda belly" oblika postave, oziroma rajenje okoli pasu.

Skratka, poleg tsh je potrebno poskrbeti, da sta ustrezna tudi ft3 in ft4, saj sicer metabolizem ne dela idealno in posledicno pride do drugih bolezni (diabetes, kardiovaskulane).Mogoce bi bilo na to dobro opozoriti na Ministrstvu za zdravje in na Nuklearni kliniki, ki se na ft3 in ft4 se vedno ne ozirajo, ce je tsh v nromalnem obmocju!!!

Sabrina

Pika, hvala.
_________________
sABrINA

Pikapolonica

aja ce je gluzkoza med 100 in 125 mg/dl je to prediabetes, ki se lahko razvije v diabetes, ce ne spemenimo zivljenjskega sloga.

Sabrina

Maj jaz mam zaenkrat znižano.
_________________
sABrINA

stane · Pridružen/-a: 19.04. 2007, 22:29 Prispevkov: 237

V trditvi, da ena bolezen povzroča drugo, ni nikakršne logike, kar dokazujejo tudi oboleli za ščitnico, saj z uživanjem ščitničnih hormonov nadomeščajo le delo ščitnice, ostali problemi pa ostajajo. Enako je z diabetiki, ki z insulinskimi injekcijami le nadomeščajo del delovanja pankreasa, ostali problemi pa ostajajo in se razvijejo v nove diagnoze.

Pikapolonica

Dragi Stane,
vidim, da so vam tezave scitnicarjev zelo pri srcu ;-).
Imate seveda vso pravico do svojega mnenja, vendar naj bi bil forum v osnovi namenjem ljudem, ki imajo s scitnico dejansko tezave.
O strokovni podlagi, kako telo deluje, kaksni so metabolni procesi,
kako deluje kemija in tudi o staticni elektriki ;-) bi se verjetno lahko marsikaj pogovorila in to malce bolj eksaktno, kot samo z mesanjem nekih povrsnih pojmov, izposojenih iz znanosti, ampak forum naj bi nudil pomoč ljudem, ki jo dejansko potrebujejo.
Lp Pika

stane · Pridružen/-a: 19.04. 2007, 22:29 Prispevkov: 237

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